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phosphorylated AMPK disrupts the localisation of pericentromeric proteins and phosphorylated Aurora A (p-Aurora A), thereby interfering with the function of the microtubule tissue centre (MTOC) [63]

Thus, considering the limitations encountered with animal models, like a low grade in mimicking the dose relevant sensitivities (132134), the proposed OoC system offered many advantages compared to classic in vitro or rodent models

Moreover, tafenoquine may be a highly useful drug to treat B

Tetraspanin-2 was found only in the unbound sample, which corroborates with other findings, which shows that the localization of tetraspanin-2 within the inner compartments of the schistosomes